HN Reader

The bit about pure THC rings true. My guy here in Britain sells live resin but occasionally when he's out of that, I'll buy one of his homebrew dab carts.

He says they are 0.4ml live resin, 0.5ml THC distillate and 0.1ml terpenes. They weigh so much heavier on my brain, and have little euphoria, compared to live resin or regular old nugs.

> weather or insects

Growers aren't really worried about them. They worried about the deadly HLVd virus. https://ceainsight.com/research-hop-latent-viroid-cannabis/

Weather is irrelevant, it's all in hightech greenhouses, with strong LED lighting, automatic watering, climate control, no insects.

The comparison to tuning a symphony vs isolating a single instrument really stuck with me. Trying to turn such a complex, variable plant into a mass-market, repeatable product seems like an uphill battle

"Cannabis scientists"? Who needs 'em...

Grow a plant, Smoke it, Enjoy...

All of the extracts, derivatives, and edibles ARE the problem. Stop concentrating the "active ingredients", and use a minimally selected variety of the plant.

As usual, all the effort going into making a shit ton of money for some rich asshole are f_cking up the original item for everyone else.

NOTE: maybe you're also familiar with a similar course of events on this thing called "the internet"?

Hey, let me know if you need anyone to help with that research.

Maybe it's only me, but "cannabis scientists" seems another one of these nonsense words that content creators make up to make their product sound smart. It slowly diffuses into mainstream journalism, and I'm really sorry for the NYTimes if their readers don't know what a chemist or biologist is. Call me Don Quixote, but I think it's a slippery slope.

Cemetery plots or stents, if you can trust the Science

E. g.,

https://www.acc.org/Latest-in-Cardiology/Journal-Scans/2025/...

https://www.healthline.com/health-news/cannabis-use-cardiova...

> to make cannabis as popular as booze requires solving that original problem: It’s hard to imagine millions of people becoming new recreational users without being able to promise them that the product they’re spending money on ... will give them the effect they want.

> it remains to be seen whether that’s even possible with a plant as complex as cannabis

Cannabis doesn't work like this. It has been tried and the end result was Sativex. It doesn't work as well as actual cannabis. It's like trying to replace coffee with caffeine. There's something like ~1000 compounds in coffee. The effects are not the same.

There's an entourage effect going on in cannabis that's extremely hard to replicate. Even buds on different parts of the same plant will have different profiles.

Also the sativa vs indica classification is almost completely meaningless nonsense these days. Does it have high THCV? Then maybe it's what was once called sativa. Was it an indica harvested before there were any amber trichomes? Maybe it has 'sativa' effects etc.

This article reads like something Vice published in 2012. Quite honestly, I only made it 1/3 through. We’ve all been to those glass case dispensaries by now. The world of weed isn’t that new and exciting anymore, c’mon guys…

They seemed to discuss reducing as much of the plant as possible to make something less variable, but smoking has gotten so many improvements what about edibles?

Just make a THC capsule that works whenever I take it, cumulatively if possible.

Not lousy gummies that I can only take once in a 24 hour cycle as my tolerance skyrockets. Followed by a hangover effect caused by as little as 10 mg.

Those current gummies, if my dosage isn’t enough and I take more later (low and slow), the second dose never quite catches up to the first one. It’s just one big non euphoric haze.

I’ve tried sublingual RSO, tinctures, and edibles. The current world of non smokable weed needs a lot of fundamental changes. It’s almost like edibles are stuck in the 70’s era of pot brownies but they reduced it down to a gummy.