I think "Last Is First" is almost like a checksum for the people writing the text, so they don't lose their place as they are copying it.
I remember having to read the Torah and it was hard to move from learning to read with standard printed Hebrew, into not only the voweless text, but with the letters stretched. You had to learn how to sing the words correctly as well.
But it was a beautiful thing to see, handwritten, fully justified, columns written with ink on parchment.