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Probably the same study from this slightly older thread https://news.ycombinator.com/item?id=41247085

Truth is many people also stop moving (exercising) significantly in their forties (reason being probably sitting lifestyle promotes posture and fascia degradation which makes moving less and less enjoyable).

I'd posit that another significant decline in moving occurs in the sixties when many go in rent.

Not sure if the biological clock is cause of abrupt changes or rather our scheduled lives. So, no significant changes from the sixties on? Then what's the genetic function of those programmations?

People who reach old age (100+) are mostly also comparatively healthy.

That's quite well-known already. The real question here: how do we stop these shifts from happening?

I'm wondering if I'm currently hitting '60' early or '40' late.

34, 60, and 78 according to this other one: https://med.stanford.edu/news/all-news/2019/12/stanford-scie...

I still stand by my claim that the most common cause of death is chronic iron poisoning, and living past 100 was a regular occurence in the bronze age.

The best explanation again seems that all the modern nutrition is nonsense fed by some double agent to the allies in WW2, (iron, and the toxicity of heavy metals) based supposedly on some secret concentration camp experiments, and nobody is allowed to question it in order to "not let their sacrifice go in vain" or some such bullshit.

After a certain age, it's important not to give a shit about irrelevant things. Otherwise the stress catches up to you.

Sounds like I still haven't gone through the molecular shifts that would have made me forget when this was first posted.

Particularly interesting is that when they split the dataset by sex, the transitions were present and at a similar magnitude in both sexes. We make much in western culture of the (peri-)menopausal change in women. I read this as an indicator that at least significant parts of the transition in this age range for men - acknowledged for a long time now - are just as big as menopause.

I don't remember noticing that the last time this study came around, but then again, I am in my mid 40s. :)

If you throw some data at a clustering algorithm, the clustering algorithm is guaranteed to give you clusters back. So I'm not convinced about the results suggesting a precise pattern of rapid aging.

Finally, science has confirmed what our grandparents told us for generations.

Ringo Starr even sang the song, "Life Begins at 40".