HN Reader

The main effect of a reaction time reduction looks incredibly small and is all the way in Fig 6. I would not over interpret this result without higher N and some discussion of effect size.

I am wondering if this related to hypoxia inducible factor (HIF) activation.

Seem to recall the nootropic Noopept allegedly acts as an activator for HIF-1. Maybe there are others. Could possibly be a therapeutic target, maybe not. This is not my area of study, I'm just reiterating some of what I've read in the past.

You mean, forcing your body into a situation where it needs more oxygen than is available is ... good for you? That sure sounds like cardio-aerobic exercise, doesn't it?

But depending on how it's done, may possibly damage your vision: https://www.sciencedirect.com/science/article/pii/S245199361...

Finally, an upside to sleep apnea

It intuitively makes sense that moderate exposure to a variety of stressors (resistance training, fasting, cold showers, sauna, sleep deprivation, etc.) forces your body to overcompensate, develop adaptations, and become more resilient.

> Healthy young adults (N = 24)

I wonder how this might figure in relation to PoTS (postural orthostatic tachycardia syndrome), either way

PoTs being where the autonomic system doesn't equalise blood pressure, especially when standing up n still for several minutes, this the brain doesn't get enough oxygen, so brain fog, head rushes, grayouts (and fatigue, temperature dysregulation + intolerance)

(I've the hyper-adrenergic variety, hyper-PoTS, where the brain tries to generate pressure in a way that will never generate pressure, leaving it so frustratingly easy to have adrenaline rushes that can last for hours)

I've seen a PoTS professional describe the effects as like kind of a mini stroke

it's getting more attention now due to the long COVID relation, and it seems that maybe microclots have become a prime suspect as a possible cause to many symptoms, though there's so many jigsaw pieces, and discerning correlation n cause n effect etc..

obviously there's many contextual tipping points between that and this study (if generalisable)

apparently I have a strong heart. idk

related;

I've nostrils with the collapsing innner valve, so I can't get deep breaths through my nose (and got getting enough air whilst sorry l asleep is a cause of bruxism)

rhinoplasty then turbinate reduction helped mildly, but apparently having some cartridge inserted would help prop the path open for a more normal use.

so,

both of these leave me feeling out of breath a lot

and it's why I'm a month breather. hopefully a third bit of surgery will finally properly help

some kinda vague anecdata there, some kind of a lens anyway!

So those breath holding contests we had at school were making us smarter?

I was given a tip to stay awake a while back: hold your breath for a little while. Apparently this well known for many years but I had never heard of it.

Seems to work, but this was in the context of driving which I do not recommend, having fallen asleep at the wheel once and woken up rally driving down some paddock.

A few days ago I linked some research to well known intervals running practice that include hypoxia: https://news.ycombinator.com/item?id=46169398

So my mild sleep apnea is a good thing, got it

I guess it worked for Deadpool.

Makes me wonder if professional divers are statistically more intelligent than average, as they will experience hypoxia as part of the job.

https://en.wikipedia.org/wiki/Professional_diving

Nisshesha Rechaka and Kapalvati prescribe very similar processes to create a similar (but different) state of hypoxia, i.e yoga

don't tell the microdosers

Sounds not very believable and probably sampling bias and other hacked research parameters.

Is this the new Adderall?

...I'm not holding my breath.

Intermittent fasting, but for oxygen. Breatharians will be elated

... note that the article linked from this discussion https://news.ycombinator.com/item?id=46168057 mentions intermittent hypoxia as a rapid acting treatment for depression right up there with Ketamine and ECT

I'm not knowledgeable enough to confidently verify this from the linked material, but aren't they keeping CO2 levels the same during the hypoxic periods? i.e. isn't this significantly different than just holding your breath/being choked/sleep apnea?

Seems like that was what they set out to prove.

Hopefully some of that can be reproduced in further studies.

Asthma counts?

I know people that live at altitude control their weight better.

I also know top athletes train in hyperbaric chambers (extra oxygen).

Autoerotic asphyxiation bros be like "hell yes, we ARE the master race"

I'd love to see them develop an at-home protocol for this, but I'm not holding my breath.

brb

Another confirmation for wim hof breathing